Beatriz Martnez-Granados1, M. Carmen Martinez-Bisbal1,2, Vicente Belloch3, J. M. Lainez4, Begoa Lpez4, Miquel Baquero5, Joaquin Escudero6, Carol Guillem6, Bernardo Celda1,2
Metabolic differences between patients with mild cognitive impairment (MCI) and Alzheimers disease (AD) by 3D CSI in small regions of parietal gray matter have been studied. 3D CSI (TE=31 ms) in a 3 T unit was performed in 54 MCI patients, 11 AD patients and 9 controls. Eight small voxels (0.75 cc) representatives of parietal gray matter were selected in two slices. NAA/Cr value was lower for AD patients than for DCL and controls in all voxels. NAA/Cr ratios were lower in the lower slice than in the upper slice. Cho/Cr ratios values also showed statistical differences between groups.