Varan Govind1, Khema R. Sharma2, Sulaiman Sheriff1, Gaurav Saigal1, Andrew A. Maudsley1
1Radiology, University of Miami, Miami, FL, United States; 2Neurology, University of Miami, Miami, FL, United States
Brain metabolite levels in the motor cortex and corticospinal tracts in earlier studies were calculated using manually drawn regions-of-interest (ROI) in those structures. Such an ROI-based data analysis approach comes with subjectivity in drawing ROIs that result in higher data variability. In this study, a 3D brain white matter CST atlas was used to analyze whole-brain MRSI data, and to quantify metabolites, N-acetyl aspartate (NAA), creatine (Cr) and choline (Cho) in the left- and right whole-CSTs of subjects with ALS and controls.