Glutamatergic & GABAergic Neurotransmission in Manganism using 13C NMR Spectroscopy

Anant Bahadur Patel¹, Puneet Bagga¹

In this study the effect of manganese induced neurotoxicity on neuronal and astroglial metabolism was evaluated by ¹³C NMR spectroscopy in conjunction with co-infusion of [U-¹³C₆]glucose and [2-¹³C]acetate. In vivo ¹H NMR spectroscopy suggested neurodegeneration in manganese treated mice. ¹³C Labeling data indicated impairment in glutamatergic, GABAergic and astroglial function in thalamus after chronic manganese treatment.