Jieun Kim1, In-Young Choi1,2, Karen Duff3, Phil Lee1,4
1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States; 2Department of Neurology, University of Kansas Medical Center, Kansas City, KS, United States; 3Department of Integrative Neuroscience, Columbia University Medical Center, New York, NY, United States; 4Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States
Effects of tauopathies in neurochemical levels of AD brain are not well understood. Tau transgenic mice (rTau) express a repressible human tau variant develop progressive age-related NFTs, neuronal loss, and behavioral impairments. In this study, we characterized neurochemical alterations associated with the development of Tau pathologies in the hippocampus and the olfactory bulbs (OB) of rTau transgenic mice. The results show that significant neurochemical changes occur in OB of rTau mice compared with wildtype.