Victor Babu Kassey1, Wesley Baker2,
Rickson C. Mesquita2, Erin Buckley Buckley2, Joel H.
Greenberg3, Eric A. Mellon1, Damodar C. Reddy1,
Arjun G. Yodth2, John A. Detre4, Mark A. Elliott1,
Ravinder Reddy1
1CMROI-Department of
Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Department
of Physics & Astronomy, University of Pennsylvania; 3Department
of Neurology, University of Pennsylvania; 4Cerebrovascular
Research Center, University of Pennsylvania, Philadelphia, United States
CMRO2 measurements are important in physiology. We have been working on T1 based indirect detection of CMRO2 on swine, a large animal model with a lung capacity comparable to humans. Though the recirculation delay for 17O is known no group has worked on 17O2 delivery in a large animal model with fast MRI combining with optical techniques to measure CMRO2 from the pre-recirculation time. In the present study, a combined integrated T1 MRI and Optical protocol has been designed to measure CMRO2 in young adult swine using two independent methods simultaneously on clinical MR scanners with the goal of future studies with humans.