Cheuk Ying Tang1,2, Emily Lauren Eaves1,
Kristen Dams-O'Connor3, Lap Ho4, David Carpenter1,
Johnny Ng1,
1Radiology, Mount Sinai
School of Medicine, New York, United States; 2Psychiatry, Mount
Sinai School of Medicine, New York, United States; 3Rehabilitation
Medicine, Mount Sinai School of Medicine, New York, United States; 4Neurology,
Mount Sinai School of Medicine, New York, United States; 5Psychiatry,
Mount Sinai School of Medicine, New York , United States
Atrophy of the corpus callosum (CC) observed after traumatic brain injury (TBI) was assessed using diffusion tensor imaging. Prior to scanning, subjects completed a series of questionnaires to assess their emotional and cognitive functioning. A single severity score was ascertained for each TBI subject. TBI subjects reported lower emotional and cognitive scores and had lower fractional anisotropy (FA) in the CC compared to controls. The severity score negatively correlated with CC FA in the TBI group. This study indicates atrophy of the CC following TBI is due to demyelination and FA may be useful as a biological marker for TBI.