Naranjargal Dashdorj1, Katherine Corrie2,
Antonio Napolitano1, Samuel Wharton3, Esben Thade
Petersen4,
1Academic Radiology,
University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Division
of Anaesthesia, University of Nottingham, Nottingham, United Kingdom; 3School
of Physics & Astronomy, University of Nottingham, Nottingham, United
Kingdom; 4National Neuroscience Institute, Singapore
Global cerebral metabolic rate of oxygen (CMRO2) and cerebral blood flow are important physiological indices of brain function and metabolism. Noninvasive measurements of these markers would be valuable in clinical neuroscience. In recent years, it has been shown that CMRO2 and CBF can be quantified using MRI techniques. Specifically, susceptometry-based oxymetry has been shown to be a quick way to quantify global cerebral metabolic changes. However, the robustness and reliability of this technique has not been tested during various physiological challenges. Quantifications of global cerebral metabolic changes during anaesthesia and different pathological conditions are of interest in neuroscience and clinical practice. This study investigated the feasibility and reliability of CMRO2 and CBF quantifications during 40% oxygen inhalation