Peter Sherman LaViolette1, Elizabeth J.
Cochran2, Mona Al-Gizawiy3, Scott D. Rand3,
Mark G. Malkin4, Jennifer Connelly4, Wade Mueller5,
Kathleen M. Schmainda3
1Biophysics, Medical College
of Wisconsin, Milwaukee, WI, United States; 2Pathology, Medical
College of Wisconsin, Milwaukee, WI, United States; 3Radiology,
Medical College of Wisconsin, Milwaukee, WI, United States; 4Neurology,
Medical College of Wisconsin, Milwaukee, WI, United States; 5Neurosurgery,
Medical College of Wisconsin, Milwaukee, WI, United States
The detection of invading brain tumor cells, beyond the traditional contrast-enhancing regions, continues to be a challenge for the treatment of brain tumors. Decreases in apparent diffusion coefficient (ADC) have been shown to correlate with an increase in tumor cellularity. Graded functional diffusion maps (gfDM) result from the subtraction and thresholding of ADC maps from multiple time points. In this study of invasive glioblastoma, we correlate in-vivo biomarkers for blood volume, and increased cellularity with ex-vivo brain tissue.