Varsha Jain1, Gaurav Jain2, Jeremy F. Magland1, Felix W. Wehrli1
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Department of Neurological Surgery, Albert Einstein College of Medicine, Bronx, NY, United States
A robust method for quantifying regional cerebral metabolic rate of oxygen consumption (rCMRO2) would be of significant clinical utility in the workup of numerous vascular pathologies affecting the brain. Currently, there are no established and reliable noninvasive methods for quantifying absolute rCMRO2. Alternate imaging methods such as positron emission tomography (PET) are limited in their use due to invasiveness and expense. Here, as an extension to the recently reported method for determining global CMRO2, we demostrate the feasibility of determining lateralized rCMRO2 corresponding to the middle cerebral artery (MCA) territory by measuring regional cerebral blood flow (rCBF) in the MCA and regional venous oxygen saturation (rSvO2) in the largest superficial cortical vein draining into the superior sagittal sinus (SSS) corresponding to the MCA vascular territory.