Manoj K. Sarma1, M. Albert Thomas1, Rajakumar Nagarajan1, April Thames2, Steven Castellon3, Elyse Singer4, Jason Smith5, Linda Croad6, Lavezza Bhatti7, Ann Ragin8, Charles Hinkin3
1Radiological Sciences, UCLA, Los Angeles, CA, United States; 2Psychiatry, UCLA School of Medicine, Los angeles, CA, United States; 3Psychiatry, UCLA School of Medicine, Los Angeles, CA, United States; 4Neurology, UCLA School of Medicine, Los Angeles, CA, United States; 5VA Greater Los Angeles Healthcare Service, Los Angeles, CA, United States; 6Kaiser Permanente Lancaster, CA, United States; 7AIDS Healthcare Foundation, Los Angeles, CA, United States; 8Radiology, Northwestern University, Chicago, IL, United States
We investigated the cortical thickness and volume across a group of Hepatitis C patients before and after interferon (IFN) therapy employing an automated method for regional parcellation. Significant increase of cortical thickness was observed in lateral occipital in both hemisphere in patients after IFN. Increase cortical volume were seen in both hemisphere at the caudal middle frontal, rostral middle frontal superior temporal and also in left precentral, left lateral orbitofrontal, right middle temporal after IFN. The areas that showed significant reduced cortical volume were left medial orbitofrontal, right fusiform and bilateral lateral occipital.