Jacobus F. A. Jansen1, Yonggang Lu2, Hilda E. Stambuk2, Nancy Y. Lee2, Jason A. Koutcher2, Amita Shukla-Dave2
An advantage of the noninvasive MRI technique is that subjects can be imagined multiple times before, during and, after treatment. In this study we assess the value of DCE-MRI derived perfusion/permeability biomarkers in predicting the short-term response to therapy in patients with head and neck squamous cell carcinoma (HNSCC) with neck nodal metastases. Sixteen patients underwent a DCE-MRI protocol before, and 10-14 days into the chemoradiation treatment. Pretreatment and early response DCE-MRI parameters were compared, and their efficacy in predicting short-term response to treatment was tested using logistic regression analysis. Pretreatment ve was a significant predictor of response. However, early response DCE marginally improves prediction of short-term response in head and neck cancer.