Ke Zhang1, Joachim Bernhard Maria Kaffanke1, Christian Fil1, Gabriele Stoffels1, Irene Neuner1,2, Karl-Josef Langen1, Hans Herzog1, N. Jon Shah1,3
1Institute of Neuroscience & Medicine 4, Medical Imaging Physics, Forschungszentrum Jlich GmbH, 52425, Juelich, Germany; 2Department of Psychiatry & Psychotherapy, JARA, RWTH Aachen University, Faculty of Medicine, 52074 Aachen, Germany; 3Faculty of Medicine, Department of Neurology, JARA, RWTH Aachen University, 52074 Aachen, Germany
PET imaging using radiolabelled amino acids tracer can specifically deliver valuable information about tumour extent, malignancy, and tumour recurrence. Perfusion MRI, which measures microcirculatory parameters such as cerebral blood flow (CBF) and cerebral blood volume (CBV), can precisely investigate vascular malformation, and help classify and grade brain tumours. In this study, FET-PET and perfusion MRI data were simultaneously acquired using a hybrid 3T MR-PET scanner [1,2]; data from a representative human brain tumour case are presented. After combination with MP-RAGE, this technique offers the opportunity to establish a reliable diagnosis of brain tumours and assessment of metabolism after therapy.