Shaolin Yang1,2, Olusola Ajilore1,
Minjie Wu3, Melissa Lamar1, Anand Kumar1
1Department of Psychiatry,
University of Illinois at Chicago, Chicago, IL, United States; 2Department
of Radiology, University of Illinois at Chicago, Chicago, IL, United States; 3Department
of Neuology, Northwestern University, Chicago, IL, United States
Type 2 diabetes and major depression are disorders that are mutual risk factors for each other. In order to understand the potentially shared pathophysiological mechanisms of these disorders, we examined their neurochemical basis using proton magnetic resonance spectroscopy at 3T. By measuring metabolites in five brain regions (anterior cingulate cortex, bilateral frontal white matter, and bilateral subcortical regions that encompassed caudate nucleus) within four different subject groups (healthy control, depressed, diabetic, and diabetic depressed), we found alteration of glutamate and glutamine, choline, and myo-inositol between these patient groups.