Daniel Han-en Chang1,2, Jeon-Hor Chen1,3, Muqing Lin1,2, Shadfar Bahri1,2, Hon J. Yu1,2, Rita S. Mehta4, Ke Nie1,2, David J. B. Hsiang5, Orhan Nalcioglu1,2, Min-Ying Lydia Su1,2
1Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, United States; 2Department of Radiological Sciences, University of California, Irvine, CA, United States; 3Department of Radiology, China Medical University Hospital, Taichung, Taiwan; 4Department of Medicine, University of California, Irvine, CA, United States; 5Department of Surgery, University of California, Irvine, CA, United States
The differences in breast density parameters and the intra-rater variability analyzed on fat-sat vs. non-fat-sat imaging sequences in women presenting central and mixed breast morphological types were investigated. The measured breast volume on fat-sat and non-fat-sat sequences was almost identical; but there was a small (<5%) difference in fibroglandular volume and percent density, higher on fat-sat sequence. Intra-operator variability was within 4% for both sequences and different breast morphological types. Analysis based on images at original and reduced spatial resolution showed a small yet significant difference, indicating the potential influence of partial volume effect on density measurements.