Tian Liu1,2, Krishna Surapaneni3, Min Lou4, Liuquan Cheng5, Jianzhong Sun6, Cynthia Wisnieff 1, 2, Craig Horenstein3, Minming Zhang6, Yi Wang1,2
1Biomedical Engineering, Cornell University, Ithaca, NY, United States; 2Radiology, Weill Cornell Medical College, New York, NY, United States; 3Radiology, Columbia University, New York, NY, United States; 4Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hang Zhou, Zhe Jiang, China, People's Republic of; 5Radiology, PLA General Hospital, Beijing, China, People's Republic of; 6Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hang Zhou, Zhe Jiang, China, People's Republic of
Gradient echo(GRE) MRI is the method of choice for detecting cerebral microbleeds(CMB) due to its sensitivity to the paramagnetic intreaparenchymal hemosiderin deposits. However, the hypointensity associated with CMB on a GRE image is highly dependent on the choice of echo time. In this study, we propose to use quantitative susceptibility mapping(QSM) as a more objective measurement of CMBs because the underlying susceptibility is theoretically independent of imaging parameter. Comparison of the T2* weighted image (T2*w), susceptibility weighted image (SWI) and R2* map showed the total susceptibility of a CMB varies the least with varying TEs.