Ferdinand Schweser1,2, Karsten Sommer1,3, Marie Atterbury1,4, Andreas Deistung1, Berengar Wendel Lehr1, Jrgen R. Reichenbach1
1Medical Physics Group, Dept. of Diagnostic & Interventional Radiology 1, Jena University Hospital, Jena, Germany; 2School of Medicine, Friedrich Schiller University of Jena, Jena, Germany; 3School of Physics & Astronomy, Friedrich Schiller University of Jena, Jena, Germany; 4Dept. of Physics, Brown University, Providence, RI, United States
In this study we investigated the impact of regularization and kernel type used with the SHARP method based on a numerical brain model. Furthermore, we present the smallest possible kernel, which allows overcoming one of the major pitfalls of SHARP, i.e. the missing values at the edges of the brain.