Valentin Gereon Kemper1, Ana-Maria
Oros-Peusquens1, Nadim Jon Shah1,2
1Institute of Neuroscience
& Medicine, Research Centre Juelich, Juelich, 52425, Germany; 2Department
of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen,
52074, Germany
Spatially resolved and correlated T1-T2 distribution spectra were obtained pixelwise in a human post mortem brain slice using multiple inversion recovery spin echo scans and 2D nonnegative least squares for data analysis. This way multiple T1 compartments can be associated with their respective T2 values. Resolution was 0.75x0.75x2mm3. The obtained spectra show characteristic distributions for different types of tissue yielding sub-pixel scaled information. The width of the white matter spectra is much wider in both, T1 and T2, supporting the assumption of multiple water compartments shown. Short and long component maps were obtained using both T1 and T2 distributions and their combination.