Jack T. Skinner1,2, Todd E. Peterson2,3,
Mark D. Does1,2
1Biomedical Engineering,
Vanderbilt University, Nashville, TN, United States; 2Institute of
Imaging Science, Vanderbilt University, Nashville, TN, United States; 3Radiology
& Radiological Sciences, Vanderbilt University, Nashville, TN, United States
A simple, two-measurement method for inverting a two-pool model with water exchange is presented. T2 measurements of injured rat skeletal muscle were made before and after contrast agent injection, from which estimates of the intrinsic extra-cellular volume fraction were computed and found to correlate strongly (R2 = 0.71) with estimates derived from SPECT imaging of an extra-cellular radiotracer.