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Abstract #2956

Evaluation of Intra-Renal Oxygenation by BOLD MRI During Water Diuresis: Race Differences

Lu-Ping Li1, Federico Mordini2, Sarah Halter1, Eugene Dunkle1, JoAnn Carbray1, Ewa Gliwa1, Hongyan Du3, Pottumarthi V Prasad1

1Radiology / Center for Advanced Imaging, Northshore University Healthsystem, Evanston, IL, United States; 2Radiology / Center for Advanced Imaging, Northshore University Healthsystem, Evanston, IL , United States; 3Center for Clinical Research Informatics (CCRI), Research Institute, Northshore University Healthsystem, Evanston, IL, United States


Prevalence of hypertension is significantly higher in the African American (AA) population compared to Caucasian (CC). A role for endothelial dysfunction has been shown based on Brachial artery ultrasonography (BAUS). Since response to water-loading on renal medullary oxygenation evaluated by BOLD MRI is also dependent on endogenous mechanisms such as prostaglandins and nitric oxide, we performed a preliminary study to evaluate these differences in a small number of healthy AA and CC. BAUS data was also obtained. Both BAUS and BOLD MRI data show reduced responses in AA, although our sample size is small to reach statistical significance.