Jionghan Dai1, Eric T. Peterson2,
James H. Holmes3, Robert V. Cadman1, Ronald L. Sorkness4,
Sean B. Fain1,5
1Medical Physics,
University of Wisconsin - Madison, Madison, WI, United States; 2Biomedical
Engineering, University of Wisconsin - Madison, Madison, WI, United States; 3Global
Applied Science Laboratory, GE Healthcare, Madison, WI, United States; 4pharmacy,
University of Wisconsin - Madison, Madison, WI, United States; 5Radiology,
University of Wisconsin - Madison, Madison, WI, United States
Noble gas MRI enables high contrast to noise dynamic imaging during respiratory maneuvers. A model of gas in-flow using linear system theory to deconvolve the dispersion at the trachea provides maps that are analogous to gas flow, while washout delay during forced exhalation provides maps of gas trapping. In this work the feasibility of these modeling approaches is evaluated in adults and children with known obstructive lung disease.