Claudia Weidensteiner1, Mehdi Ordikhani-Seyedlar2, Anna Werres3, Nadja Osterberg3, Astrid Weyerbrock3, Wilfried Reichardt2
1MR Development & Application Center, University Medical Center Freiburg, Freiburg, Germany; 2Department of Radiology/Medical Physics, University Medical Center Freiburg, Freiburg, Germany; 3Department of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany
The treatment effect of the chemotherapeutic drug temozolomide (TMZ) in combination with the nitric-oxide donor JS-K was investigated with DCE-MRI in rat gliomas in vivo. Nitric-oxide donors can enhance the transport of drugs to brain tumors. The acute effect of JS-K was an increase in permeability of the blood-tumor barrier and/or tumor perfusion. After 1 week of treatment there was a significant decrease in tumor permeability/perfusion and tumor size for TMZ and TMZK as compared to control. JS-K alone had no effect. TMZK led to an increased edema formation but showed otherwise no difference to TMZ alone.