Mark Alan Rosen1, Yiqun Xue1,
Sarah Englander1, Daniel Heitjian2, Hyunseon S. Kang1,
Anna Fagan1, Naomi Haas3, William Lee3,
William Carley4, Hee Kwon Song1, Stephen Keefe3,
Yu Jiangsheng1
1Radiology, University of
Pennsylvania, Philadelphia, PA, United States; 2Biostatistics and
Epidemiology, University of Pennsylvania, Philadelphia, PA, United States; 3Medicine,
University of Pennsylvania, Philadelphia, PA, United States; 4Pfizer,
Inc., Collegeville, PA, United States
Acquisition of hybrid radial projection DCE-MRI allows for large volume perfusional imaging with rapid temporal resolution in human tumor studies. We studied ten patients with metastatic RCC before and early after initiation of therapy with Sunitinib. Tumor Ktrans, kep and Ve were all significantly decreased after therapy. Inclusion of intra-tumoral vascular volume significantly altered the magnitude of tumor DCE-MRI metrics, and provided evidence of therapy-induced reductions in both tumor vascular permeability and tumor vascular volume.