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Abstract #3153

Differentiation of Radiation Necrosis from Glioma in Rat Models using Diffusion Tensor MR Imaging

Silun Wang1, Yifei Chen1, Bachchu Lal2,3, Eric Ford4, Erik Tryggestad4, Michael Armour4, Kun Yan1, John Laterra2,5, Jinyuan Zhou1,6

1Radiology, Johns Hopkins School of Medicine, Baltimore, MD, United States; 2Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States; 3Neurology, Kennedy Krieger Institute, Baltimore, MD, United States; 4Radiation Oncology, Johns Hopkins School of Medicine, Baltimore, MD, United States; 5Neurology , Kennedy Krieger Institute, Baltimore, MD, United States; 6F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States


We evaluated the DTI features of brain radiation necrosis (40 Gy, 1010 mm2) and 9L and GBM22 glioma models in rats. Results indicated that radiation necrosis consisted of a hyperintense rim and a hypointense central zone, compared to the contralateral hemisphere. There was decreased directionality and magnitude of water diffusion in the lesion of radiation necrosis, particularly in its central zone. Qualitative and quantitative analysis of DTI indices provides useful information to differentiate between radiation necrosis and glioma in rat models.