Pratip Bhattacharya1, Niki Zacharias1, William H. Perman2, Asraf Imam1, Alan Epstein3, Brian D. Ross1
1Enhanced MR Laboratory, Huntington Medical Research Institutes, Pasadena, CA, United States; 2Medical Physics, St. Louis University, St. Louis, MO, United States; 3Pathology, University of Southern California, Los Angeles, CA, United States
The objective of this work was to overcome inherent insensitivity of in vivo MR by demonstrating metabolic imaging of the Succinate Dehydrogenase oncogene expression. This was accomplished by imaging the products of Krebs Tricarboxylic Acid Cycle in vivo using PHIP (Parahydrogen Induced Imaging) modality of hyperpolarization in real time in two tumor bearing mice models-a) RENCA renal cancer and b) Lymphoma A20. Hyperpolarized C-13 labeled succinate is shown to interrogate different steps of TCA cycle metabolism and image the SDH oncogene expression in real time.