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Abstract #3203

Phosphocreatine & Acetylcarnitine in Skeletal Muscle During Exercise at 7T by Interleaved 31P & 1H-MRS

Katja Heinicke1,2, Jackson Green1,2, Ivan Dimitrov3,4, Sergey Cheshkov3, Jimin Ren3, Craig R. Malloy3, Ronald G. Haller1,2

1Neuromuscular Center, Institute for Exercise & Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, United States; 2Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States; 3Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 4Philips Medical Systems, Cleveland, OH, United States


31P-MRS provides insight into muscle energy metabolism, and 1H-MRS offers direct measurement of intramyocellular lipid concentration and the concentration of acetylcarnitine which is important for characterizing mitochondrial function and integrity.