Hermien E. Kan1, Sebastian Aussenhofer1, Andrew Webb1, Aranee Techawiboonwong2, Itamar Ronen1
1Radiology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands; 2Department of Electrical Engineering, Mahidol University, Nakornpathom, Thailand
Assessment of diffusive properties of phosphorous metabolites using diffusion tensor spectroscopy (DTS) has so far been limited to animal studies. 31P DTS of the phosphocreatine signal could provide a useful method to probe intracellular space in humans, as it is not present in the same compartment as the adipose tissue that influences DTI measurements of skeletal muscle. In this study, we show, for the first time in humans, that it is feasible to obtain ADC and FA values of different skeletal muscles in the human calf using 2D 31P DT CSI and a newly developed coil design for 7T.