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Abstract #3380

Pancreatic Exocrine Function & Cardiac Iron in Patients with Iron Overload & with Thalassemia

Jin Yamamura1, Regine Grosse2, Andrea Jarisch3, Gritta E. Janka4, Peter Nielsen5, Gerhard Adam1, Roland Fischer5,6

1Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 2Pediatric Hematology & Oncology, University Medical Center Hamburg-Eppendorf; 3Stem Cell Transplant Center, Johann Wolfgang Goethe-University of Frankfurt, Frankfurt, Germany; 4Pediatric Hematology & Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 5Department of Biochemistry & Molecular Biology II: Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 6Childrens Hospital & Research Center Oakland, Oakland, CA, United States


In patients with iron overload, assessment of cardiac iron by fast MRI-R2/R2* methods has become a standard of care. We measured R2* relaxation rates in the myocardium by MRI in comparison with the exocrine pancreatic function by means of serum pancreatic enzyme determination in patients with -thalassemia.Patients at risk of elevated cardiac iron levels could be identified by the exocrine pancreatic lipase and amylase function parameters.