Thomas William Okell1, Michael Andrew
Chappell1,2, Ursula G. Schulz3, Peter Jezzard1
1FMRIB Centre, Department
of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, United
Kingdom; 2Institute of Biomedical Engineering, University of
Oxford, Oxford, Oxfordshire, United Kingdom; 3Stroke Prevention
Research Unit, Department of Clinical Neurosciences, University of Oxford,
Oxford, Oxfordshire, United Kingdom
A theoretical framework for the quantification of vessel-encoded arterial spin labeling dynamic angiography is presented and illustrated by application in a healthy volunteer and patient with vertebral stenosis. The calibration factor that relates the measured signal to blood volume can be robustly determined using the same data, avoiding the need for separate calibration scans. The derived volume flow rates are consistent with those in the literature and capable of clearly showing the level of collateral flow in patient studies.