Abstract #3410

Dual Manganese- & Delayed-Enhanced MRI Detects Myocardial Border Zone Viability in a Murine Myocardial Injury Model

Ildiko Toma¹, Michael Qian², Jaehoon Chung¹, Yongquan Gong³, Rajesh Dash¹, Robert C. Robbins⁴, Philip Harnish⁵, Phillip C. Yang¹

¹Medicine/Cardiovascular Medicine, Stanford University, Stanford, CA, United States; ²University of California, Berkeley, Berkeley, CA, United States; ³Radiology, Stanford University, Stanford, CA, United States; ⁴Cardiothoracic Surgery - Adult Cardiac Surgery, Stanford University, Stanford, CA, United States; ⁵Eagle Vision Pharmaceutical Corp., United States

Delayed enhancement MRI (DEMRI) identifies non-viable myocardium, but is non-specific and may overestimate nonviable territory. Manganese enhanced MRI (MEMRI) signal identifies manganese in viable cells. We performed dual-contrast myocardial assessment, combining DEMRI and MEMRI in a diabetic murine acute infarct model to characterize border zone viability in vivo. MEMRI demonstrated smaller scar volume and percentage compared to DEMRI. Dual-contrast MEMRI-DEMRI may identify at-risk but viable myocardial cells within transmural DEMRI regions.