Sandeep Kumar Ganji1, Ivan E. Dimitrov1,2, Elizabeth A. Maher3, Changho Choi1
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Philips Medical Systems, Cleveland, OH, United States; 3Internal Medicine & Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States
Alterations in glutamate (Glu) and glutamine (Gln) levels have been reported in several brain tumors ex-vivo and in vivo. Spectroscopic imaging of Glu and Gln in vivo remains challenging due to spectral overlaps and low signal intensities. Here we report Glu and Gln spectroscopic imaging employing an optimized-TE PRESS-based method. We present the in-vivo data from healthy volunteers and brain tumor patients. The concentration maps of metabolites are reported.