Selective Zero-Quantum Coherence Transfer (Sel-ZQC) Method for High-Resolution Metabolite Imaging at Ultrahigh Field without Inhomogeneous Broadening & Susceptibility Artifacts

Song Chen¹, Qiuhong He^1,2

The Sel-ZQC pulse sequences were developed to detect the high-resolution zero-quantum NMR signals of metabolites without subjecting to inhomogeneous broadening and magnetic susceptibility artifacts at ultrahigh fields. The sequence completely suppresses the lipid and water resonances that block the observation of metabolite signals. The in vivo Sel-ZQC method may be applied to study breast cancer or other human diseases in extracranial organs in the presence of high mobile fat concentration.