Silvina G. Horovitz1, Brian D. Berman1,2, Mark Hallett1
1HMCS, NINDS - NIH, Bethesda, MD, United States; 2Neurology, School of Medicine University of Colorado Denver, Aurora, CO, United States
Functional connectivity resting state based on BOLD functional MRI (fMRI) has been used mainly to observe brain networks while subjects do nothing. The same principle, however, can be used for any other steady-state brain condition. In this study, we compare the connectivity of the motor area during hand movement imagery with and without real time neuro-feedback of BOLD signal of the hand motor area. We observed connectivity changes during neuro-feedback runs; these changes were maintained through a subsequent run without neuro-feedback.