R. Matthew Hutchison1, L. Stan Leung1,
Seyed M. Mirsattari1, Joseph S. Gati2, Ravi
1University of Western
Independent component analysis of the resting macaque brain revealed homologous large-scale network organization at multiple levels of processing with humans. These included higher-order networks facilitating executive functioning, attentional processing, reward evaluation, and default-mode activity as well as lower-order networks responsible for vision, audition, sensorimotor integration, and motor control. The consistency of RSNs between macaques and humans suggests the same gross topological cortical organization, thereby providing strong support for their use as an animal model in the study of normal and abnormal functional connectivity.