Lirong Yan1, Robert P. Spunt2, Emily Kilroy1, Matthias Gunther3, Matthew D. Lieberman2, Danny J. J. Wang1
1Department of Neurology,
Although gradient-echo EPI is widely used for BOLD fMRI, it suffers from susceptibility artifacts, and the temporal resolution is generally on the order of 2 to 3s for whole brain coverage. In the present study, we used 3D GRASE with asymmetric spin-echo (ASE) for fMRI with a temporal resolution of 1s per brain volume. Compared to standard 2D EPI, GRASE with ASE not only achieved superior sensitivity in visual cortex activation, but also uniquely detected prefrontal activation during a Go/No-Go task.