Christopher Paul Pawela1,2, Bharat B. Biswal3, Rupeng Li2, Anthony G. Hudetz4, James S. Hyde2
1Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI, United States; 2Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 3Department of Radiology, University of Medicine & Dentistry of New Jersey, Newark, NJ, United States; 4Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, United States
Resting-State Functional Connectivity MRI (fcMRI) is finding application in studying a variety of brain disorders. The underlying physiological basis of the BOLD resting-state fluctuations is still unknown. In this study, manipulation of the peripheral nervous system is performed to modify signal input into the thalamocortical system and disrupt interhemispheric correlation of the sensorimotor system. This study demonstrates the bilateral nature of resting-state correlation and may provide insight into the phenomenon.