Alex Xuexin Li1, Mojmir Suchy1,2, Joseph S. Gati1, Robert H. E. Hudson2, Ravi S. Menon1,3, Robert Bartha1,3
1Robarts Research Institute, the University of Western Ontario, London, ON, Canada; 2Department of Chemistry, the University of Western Ontario, London, ON, Canada; 3Department of Medical Biophysics, the University of Western Ontario, London, ON, Canada
A Dy3+-DOTAM-Gly-Lys PARACEST contrast agent with a bound water chemical shift (~ -670 ppm) well beyond the endogenous magnetization transfer (MT) window was used for temperature mapping. The endogenous MT effect did not decrease the CEST sensitivity of bound water, and an accurate and precise temperature image was generated from this compound in solution and bovine serum albumin. This compound may be effective for temperature mapping with a temperature sensitivity 20 times larger than that for europium-based agents.