Jiming Zhang1, Pei-Herng Hor1,
John Fischer2, Ari Partanen3, Tiina Karjalainen3,
Raja Muthupillai2
1Department of Physics
& Texas Center for Superconductivity, University of Houston, Houston, TX,
United States; 2Diagnostic & Interventional Radiology, St.
Luke's Episcopal Hospital, Houston, TX, United States; 3Clinical
Science, Philips Medical Systems, Cleveland, OH, United States
We propose a theoretical model utilizing a temperature dependent perfusion term for simulating the temperature evolution during and following MR-HIFU therapy in a pig model. The results from the theoretical model match closely with experimental observations. Key insights from our study are the following: (a) Local tissue perfusion responses in MR-HIFU are much dynamic than what has been reported in hyperthermia applications; (b) A temperature dependent perfusion term is necessary for adequately modeling the temperature evolution in MR-HIFU, and (c) Tissue perfusion response to MR-HIFU must be taken into account in clinical HIFU therapy planning and optimization