Nicole Azene1,2, Yingli Fu1, Tina Ehtiati3, Aaron Flammang3, Dorota Anna Kedziorek1, Jens Guehring4, Wesley D. Gilson3, Judy Cook1, Clifford R. Weiss1, Kathleen L. Gabrielson2, Peter V. Johnston5, Dara L. Kraitchman1
1Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2Molecular & Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 3Siemens Corporate Research, Baltimore, MD, United States; 4Siemens Corporate Research, Erlangen, Germany; 5Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States
Traditionally, cardiac cellular therapeutics have been delivered directly to the myocardium or coronary vasculature. An intrapericardial (IP) approach would potentially provide a method for long-term retention of stem cells. In the current study, the feasibility of a fused X-ray-magnetic resonance imaging (XFM) method was explored for delivery of an X-ray visible barium-alginate microcapsule (BaCaps) in swine. XFM-guidance was shown to enhance safety, e.g., provide enhanced soft tissue detail and vessel anatomy, and improve biocompatibility of BaCap delivery. Thus XFM IP delivery of cardiac therapeutics shows promise for the use of BaCaps for allogenic stem cell delivery.