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Abstract #3901

Effects of Artery Input Function on Dynamic Contrast Enhanced MRI for Determining Grades of Gliomas

Na Zhang1, Lijuan Zhang1, Xin Liu1, Hairong Zheng2, Jeffrey Carpenter3, Bob L. Hou3

1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen, Guangdong, China, People's Republic of; 2Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen, Guangdong, China, People's Republic of; 3Radiology, West Virginia University, Morgantown, WV, United States


To select an optimum brain artery for generating an artery input function (AIF) is the most important step for differentiating gliomas. We applied a modified two-compartment Tofts model to calcalate Ktrans and Ve, and compared the values obtained by using different AIFs in four grades of gliomas (determined by biopsy) for evaluating impacts of the AIFs on grading the tumors. We found that selecting an AIF from MCA is the