Cing-Ciao Ke1, Shin-Lei Peng1, Chih-Feng Chen2, Ho-Lin Liu3, Fu-Nien Wang1
1Biomedical Engineering & Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 2Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan; 3Medical Imaging & Radiological Sciences, Chang Gung University, Taoyuan, Taiwan
The previous study only demonstrated that liner least-squares (LLSQ) method may be more useful method than nonlinear least Vsquares NLSQ method in solving modification of Tofts and Kermode. We performed computer simulations to assess the accuracy of estimating the kinetic parameters for LLSQ and NLSQ methods in solving Tofts and Kermode model. At lower signal-to-noise (SNR), the accuracy of parameters estimated with LLSQ method is better than NLSQ method. Besides, the calculation velocity of LLSQ method was seventeen times faster than NLSQ method.