David Thomas Pilkinton1,2, John A. Detre2,3, Ravinder Reddy1,2
1Biochemistry & Molecular Biophysics, University of Pennsylvania, Philadelphia, PA, United States; 2Center for Magnetic Resonance & Optical Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 3Center for Functional Neuroimaging, Unversity of Pennsylvania, Philadelphia, PA, United States
A number of studies have used ASL approaches to investigate the regional CBF changes with hyperoxia. Although it is well-known that inhaled oxygen creates a significant reduction in the T1 of arterial blood (T1a), only a minority of these studies have incorporated T1a changes in their ASL calculations. In this study, we simultaneously measured CBF and T1a in vivo during hyperoxia using a PASL approach in the rat brain at 3T. These data allow for correction per subject basis to quantify the degree to which the reduction in CBF measured with ASL is due to the reduction in T1a.