Jeffry R. Alger1,2, T. J. Schaewe, D. S.
Liebeskind, J. L. Saver, C. S. Kidwell3
1Neurology, Geffen School
of Medicine at UCLA, Los Angeles, CA, United States; 2Radiological
Sciences, Geffen School of Medicine at UCLA, Los Angeles, CA, United States; 3Neurology,
Georgetown University, Washington, DC, United States
The feasibility of half dose (0.05 mmol/kg) DSC microvascular perfusion MRI for stroke evaluation was assessed in normal subjects and by computer simulation under conservative 1.5 T imaging conditions. Results suggest that half dose DSC is feasible. This suggests the possibility reduced gadolinium exposure in routine stroke imaging and clinical trials that use MRI for assessment of stroke therapy.