Shujuan J. Fan1,2, Frank Yik Hin Lee1,2, Matthew Man Hin Cheung1,2, April Mei Kwan Chow1,2, Zhongwei W. Qiao1,2, Kevin Chuen Wing Chan1,2, Ed X. Wu1,2
1Laboratory of Biomedical Imaging & Signal Processing, the University of Hong Kong, Hong Kong SAR, China, People's Republic of; 2Department of Electrical & Electronic Engineering, the University of Hong Kong, Hong Kong SAR, China, People's Republic of
Secondary neurodegeneration in substantia nigra (SN) has been commonly observed in ischemic strokes. However, little is known about such degeneration in intracerebral hemorrhage (ICH). In this study, multi-parametric MRI was employed to characterize the evolution of such injuries and understand the underlying pathological changes. The injury was first detected by DTI at day 1 after ICH, and was characterized by dramatic diffusivity decrease, elevated T2 relaxation times at day 3, and gradually increased T1W signal intensities. These results suggested that DTI could be utilized for early diagnosis for secondary SN injury, which would be long-lasting and progressive and worth attention.