Edward S. Hui1, Fang Du1, Qiang Shen1, Shiliang Huang1, Timothy Q. Duong1
1Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, United States
The outcome of stroke treatment relies in large part on reliable staging of ischemic tissue. With the high sensitivity and specificity of conventional DWI in ischemic tissue delineation, additional clinically relevant information regarding ischemic tissue microstructure should be probed using diffusion kurtosis imaging (DKI). The goal of this study was to explore what additional DKI data could offer in ischemic stroke rat during hyperacute and acute phases. The current study shows that MK is a sensitive index of hyperacute ischemic injury, and increases with time from hyperacute to acute phase, offering a valuate tool to better stage ischemic brain injury.