Yimin Shen1, Weili Zheng1, Yu-Chung N. Cheng1, Yuchuan Ding2, Jean Sebastien Raynaud3, E. Mark Haacke1
Our purpose is to determine if USPIO high resolution SWI at 7T sufficiently aid in visualization of collateral vessels in the penumbral area of lesions in a rat MCAO stroke model. Stroke in rats was induced by a 2-hour right MCAO using an intraluminal filament. MRI scans were performed on no stroke (n=1), stoke no treatment (n=5), stroke with sildenafil treatment rats (n=6) at four time points: baseline, 24h post MCAO, two weeks, four weeks. SWI shows clearly the presence of newly developed vessels near periphery of ischemic core in sildenafil treated severe stroke animals after two-week MCAO but not shows in mild stroke animals.