Ivan Kirov1, Assaf Tal1, James Babb1, Joseph Reaume1, Robert Grossman1, Oded Gonen1
Quantitative MR studies in mild traumatic brain injury report conflicting results on the sites and types of injury. This implies that damage is heterogeneous, diffuse and minimal. We employed three-dimensional proton MR spectroscopy to assess metabolic concentrations in all gray and white matter within the volume-of-interest of 22 patients and 11 controls. This resulted in increased sensitivity to diffuse injury in each tissue type, while suffering minimal partial volume effects owing to small (0.75 cc) voxels. The results revealed no evidence of brain atrophy, glial or energy abnormalities and a statistical trend suggesting neuronal damage in the white matter.