Jenny Wu1,2, Erik B. Beall1, Mark J. Lowe1, Benjamin L. Walter3,4, Andre Machado5, Micheal D. Phillips1
1Imaging Institute, Cleveland Clinic, Cleveland, OH, United States; 2New York Medical College, Valhalla, NY, United States; 3Neurological Institute, University Hospitals Case Medical Center, Cleveland, OH, United States; 4Case Western Reserve University School of Medicine, Cleveland, OH, United States; 5Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, United States
This study compared resting state functional connectivity in a Parkinson's Disease (PD) patient between on and off subthalamic nucleus deep brain stimulation (STN-DBS) conditions. MPRAGE and resting state fMRI studies were acquired from a unilateral STN-DBS PD patient. Seed-based correlation analyses using basal ganglia regions of interest generated z-score maps of significant correlation to each region. Stimulation decreased bilateral connectivity in putamen and globus pallidus but increased thalamic connectivity with supplementary motor areas. These stimulation-associated changes may be involved with desynchronization of pallidal output to thalamus leading to strengthened connectivity to cortical areas.