Joao M. N. Duarte1,2, Rolf Gruetter1,3
1Laboratory for Functional
& Metabolic Imaging, Center for Biomedical Imaging, Ecole Polytechnique,
Lausanne, Vaud, Switzerland; 2Faculty of Biology & Medicine,
University of Lausanne, Lausanne, Switzerland; 3Department of
Radiology, Universities of Lausanne & Geneva, Lausanne, Switzerland
The concentration of metabolites in different cerebral areas, so called neurochemical profile, can be taken as biomarker of regional development, differentiation or degeneration. Aging-associated functional alterations may be accompanied by neurochemical alterations that were now evaluated in aging mice, using in vivo proton spectroscopy at 14.1 T.