Vaishali Tomar1, Abhishek Yadav1, Vikas Bharadwaj2, Bal Kishan Ojha2, Kashi Nath Prasad3, Ram Kishan Singh Rathore4, Rakesh Kumar Gupta1
1Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 2Neurosurgery, Chatrapati Sahu ji Maharaj Medical University, Lucknow, Uttar Pradesh, India; 3Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 4Mathematics & Statistics, Indian Institute of Technology, Kanpur, Kanpur, Uttar Pradesh, India
DWMRI was performed on 15 patients with brain abscess. DW imaging was performed with b-values 1000 s/mm2, 2000 s/mm2, and 3000 s/mm2. The mean ADC values were quantified from ADC maps of different b-values generated from DWI data. We have calculated total viable cells per unit area in the abscess cavity. The mean ADC values were quantified from abscess cavity at different b-values. We found that as the b-value increases, mean ADC value decreases. A significant negative correlation was observed between cell counts and ADC values at different b-values. At b=3000 s/mm2 we got a near to perfect negative correlation between mean ADC and viable cell counts. The high b value picks more viable cells in the abscess cavity suggests that viability of cells in the abscess cavity represents the activity of diseases. In the BA b=3000 s/mm2 may predict activity of the diseases in response to therapy.