Manoj K. Sarma1, M. Albert Thomas1, Rajakumar Nagarajan1, April Thames2, Steven Castellon3,4, Elyse Singer5, Jason Smith4, Jonathan Truong6, Homayoon Khanlou7, Ann Ragin8, Charles Hinkin3,4
1Radiological Sciences, UCLA, Los Angeles, CA, United States; 2Psychiatry, UCLA School of Medicine, Los angeles, CA, United States; 3Psychiatry, UCLA School of Medicine, Los Angeles, CA, United States; 4VA Greater Los Angeles Healthcare Service, Los Angeles, CA, United States; 5Neurology, UCLA School of Medicine, Los Angeles, CA, United States; 6Kaiser Permanente Lancaster, CA, United States; 7AIDS Healthcare Foundation, Los Angeles, CA, United States; 8Radiology, Northwestern University, Chicago, IL, United States
Both Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) have same routes of transmission, but little is known about how the co-infection effect the cortex. We have done a cortical surface-based analysis of the whole cortical mantle to investigate the cortical thickness/volume and cerebral white matter (WM) volume across a group of HCV/HIV co-infected and HCV mono-infected adult patients. Our results showed widespread brain regions with thinning of cortical thickness (CT) in HCV/HIV co-infected adults relative to HCV mono-infected. Thickening of CT is also seen in some regions. We also observed cerebral WM volume and cortical volume changes.